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Journal of Virology, January 2005, p. 853-859, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.853-859.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Selection for Virulent Dengue Viruses Occurs in Humans and Mosquitoes

Raymond Cologna, Philip M. Armstrong, and Rebeca Rico-Hesse*

Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas

Received 7 July 2004/ Accepted 18 August 2004

Dengue is the most common mosquito-borne viral disease in humans. The spread of both mosquito vectors and viruses has led to the resurgence of epidemic dengue fever (a self-limited flu-like syndrome) and the emergence of dengue hemorrhagic fever (severe dengue with bleeding abnormalities) in urban centers of the tropics. There are no animal or laboratory models of dengue disease; indirect evidence suggests that dengue viruses differ in virulence, including their pathogenicities for humans and epidemic potential. We developed two assay systems (using human dendritic cells and Aedes aegypti mosquitoes) for measuring differences in virus replication that correlate with the potential to cause hemorrhagic dengue and increased virus transmission. Infection and growth experiments showed that dengue serotype 2 viruses causing dengue hemorrhagic fever epidemics (Southeast Asian genotype) can outcompete viruses that cause dengue fever only (American genotype). This fact implies that Southeast Asian genotype viruses will continue to displace other viruses, causing more hemorrhagic dengue epidemics.

* Corresponding author. Mailing address: Department of Virology and Immunology, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227. Phone: (210) 258-9681. Fax: (210) 258-9776. E-mail: rricoh{at}sfbr.org.

Journal of Virology, January 2005, p. 853-859, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.853-859.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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