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Journal of Virology, January 2005, p. 1333-1336, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.1333-1336.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Older Rhesus Macaque Infants Are More Susceptible to Oral Infection with Simian-Human Immunodeficiency Virus 89.6P than Neonates

Agnès-Laurence Chenine,1,2 Flavia Ferrantelli,1,2 Regina Hofmann-Lehmann,1,2 Mark G. Vangel,3,4 Harold M. McClure,5 and Ruth M. Ruprecht1,2*

Department of Cancer Immunology and AIDS,1 Department of Biostatistics, Dana-Farber Cancer Institute,3 Department of Medicine, Harvard Medical School,2 Harvard School of Public Health, Boston, Massachusetts,4 Yerkes National Primate Research Center, Emory University, Atlanta, Georgia5

Received 25 May 2004/ Accepted 3 September 2004

Earlier primate studies revealed that oral transmission of immunodeficiency viruses can occur at all ages [R. M. Ruprecht et al., J. Infect. Dis. 179(Suppl. 3):S408-S412, 1999]. Using a stock of pathogenic simian-human immunodeficiency virus, SHIV89.6P, we compared the 50% animal infectious dose needed to achieve systemic infection after oral challenge in newborn and older infant or juvenile rhesus macaques. Unexpectedly, the older monkeys required a 150-fold-lower virus challenge dose than the neonates (P = 3.3 x 10–5). In addition, at least 60,000 times more virus was needed to achieve systemic infection in neonates by the oral route than by the intravenous route (P < 1 x 10–5). Thus, route of inoculation and age are important determinants of SHIV89.6P infectivity in rhesus macaques.

* Corresponding author. Mailing address: Dana-Farber Cancer Institute, 44 Binney Street, JFB809, Boston, MA 02115-6084. Phone: (617) 632-3719. Fax: (617) 632-3112. E-mail: ruth_ruprecht{at}dfci.harvard.edu.

Journal of Virology, January 2005, p. 1333-1336, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.1333-1336.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Song, R. J., Chenine, A.-L., Rasmussen, R. A., Ruprecht, C. R., Mirshahidi, S., Grisson, R. D., Xu, W., Whitney, J. B., Goins, L. M., Ong, H., Li, P.-L., Shai-Kobiler, E., Wang, T., McCann, C. M., Zhang, H., Wood, C., Kankasa, C., Secor, W. E., McClure, H. M., Strobert, E., Else, J. G., Ruprecht, R. M. (2006). Molecularly Cloned SHIV-1157ipd3N4: a Highly Replication- Competent, Mucosally Transmissible R5 Simian-Human Immunodeficiency Virus Encoding HIV Clade C env.. J. Virol. 80: 8729-8738 [Abstract] [Full Text]  


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