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Journal of Virology, October 2005, p. 12597-12601, Vol. 79, No. 19
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.19.12597-12601.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus Type 1 gp120 and Other Activation Stimuli Are Highly Effective in Triggering Alpha Interferon and CC Chemokine Production in Circulating Plasmacytoid but Not Myeloid Dendritic Cells

Manuela Del Cornò,1,{dagger} Maria Cristina Gauzzi,1,{dagger} Giuseppe Penna,2 Filippo Belardelli,1 Luciano Adorini,2 and Sandra Gessani1*

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy,1 BioXell, Milan, Italy2

Received 5 April 2005/ Accepted 11 July 2005

Exposure to aldrithiol-2-inactivated human immunodeficiency virus type 1 or gp120, but not gp41, triggered alpha interferon (IFN-{alpha}), CC chemokine ligand 2 (CCL2), CCL3, and CCL4 production in human plasmacytoid dendritic cells (DCs) but not in myeloid DCs (M-DCs) or monocyte-derived DCs from the same donors. The nonresponsiveness of M-DCs for IFN-{alpha}/ß production was a general feature specific to these cells, as they also failed to produce it in response to inactivated influenza virus, poly(I-C), lipopolysaccharide, Staphylococcus aureus Cowans I, or CD40L. The different capacities of circulating DC subsets to produce immune mediators in response to most stimuli argue for a different role for these cells in the regulation of innate immunity to pathogens.

* Corresponding author. Mailing address: Istituto Superiore di Sanità, Department of Cell Biology and Neurosciences, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 3906-49903169. Fax: 3906-49903641. E-mail: gessani{at}iss.it.

{dagger} Manuela Del Cornò and Maria Cristina Gauzzi equally contributed to this work.

Journal of Virology, October 2005, p. 12597-12601, Vol. 79, No. 19
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.19.12597-12601.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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