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Journal of Virology, October 2005, p. 12592-12596, Vol. 79, No. 19
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.19.12592-12596.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus

Sanchita Bhadra, Mary M. Lozano, and Jaquelin P. Dudley*

Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712

Received 29 April 2005/ Accepted 5 July 2005

Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.

* Corresponding author. Mailing address: Section of Molecular Genetics and Microbiology, The University of Texas at Austin, One University Station, A5000, 24th Street and Speedway, ESB 226, Austin, TX 78712-0162. Phone: (512) 471-8415. Fax: (512) 471-7088. E-mail: jdudley{at}uts.cc.utexas.edu.

Journal of Virology, October 2005, p. 12592-12596, Vol. 79, No. 19
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.19.12592-12596.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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