This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Abel, K.
Right arrow Articles by Miller, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abel, K.
Right arrow Articles by Miller, C. J.

 Previous Article  |  Next Article 

Journal of Virology, October 2005, p. 12164-12172, Vol. 79, No. 19
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.19.12164-12172.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Temporal and Anatomic Relationship between Virus Replication and Cytokine Gene Expression after Vaginal Simian Immunodeficiency Virus Infection

Kristina Abel,1,2,3* David M. Rocke,2,4 Barinderpal Chohan,1,2 Linda Fritts,1,2 and Christopher J. Miller1,2,3,5

Center for Comparative Medicine,1 California National Primate Research Center,2 Department of Internal Medicine, Division of Infectious Diseases, School of Medicine,3 Division of Biostatistics,4 Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California at Davis, Davis, California5

Received 16 May 2005/ Accepted 5 July 2005

The current knowledge about early innate immune responses at mucosal sites of human immunodeficiency virus (HIV) entry is limited but likely to be important in the design of effective HIV vaccines against heterosexual transmission. This study examined the temporal and anatomic relationship between virus replication, lymphocyte depletion, and cytokine gene expression levels in mucosal and lymphoid tissues in a vaginal-transmission model of HIV in rhesus macaques. The results of the study show that the kinetics of cytokine gene expression levels in the acute phase of infection are positively correlated with virus replication in a tissue. Thus, cytokine responses after vaginal simian immunodeficiency virus (SIV) inoculation are earliest and strongest in mucosal tissues of the genital tract and lowest in systemic lymphoid tissues. Importantly, the early cytokine response was dominated by the induction of proinflammatory cytokines, while the induction of cytokines with antiviral activity, alpha/beta interferon, occurred too late to prevent virus replication and dissemination. Thus, the early cytokine response favors immune activation, resulting in the recruitment of potential target cells for SIV. Further, unique cytokine gene expression patterns were observed in distinct anatomic locations with a rapid and persistent inflammatory response in the gut that is consistent with the gut being the major site of early CD4 T-cell depletion in SIV infection.

* Corresponding author: Mailing address: UC Davis, CCM/CNPRC, County Rd. 98/Hutchison Dr., Davis, CA 95616. Phone: (530) 754-5673. Fax: (530) 754-4411. E-mail: kabel{at}ucdavis.edu.

Journal of Virology, October 2005, p. 12164-12172, Vol. 79, No. 19
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.19.12164-12172.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Durudas, A., Milush, J. M., Chen, H.-L., Engram, J. C., Silvestri, G., Sodora, D. L. (2009). Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in Simian Immunodeficiency Virus-Infected Monkeys. J. Virol. 83: 12229-12240 [Abstract] [Full Text]  
  • Fontenot, D., He, H., Hanabuchi, S., Nehete, P. N., Zhang, M., Chang, M., Nehete, B., Wang, Y.-H., Wang, Y.-H., Ma, Z.-m., Lee, H.-C., Ziegler, S. F., Courtney, A. N., Miller, C. J., Sun, S.-C., Liu, Y.-J., Sastry, K. J. (2009). TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc. Natl. Acad. Sci. USA 106: 16776-16781 [Abstract] [Full Text]  
  • Stacey, A. R., Norris, P. J., Qin, L., Haygreen, E. A., Taylor, E., Heitman, J., Lebedeva, M., DeCamp, A., Li, D., Grove, D., Self, S. G., Borrow, P. (2009). Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections. J. Virol. 83: 3719-3733 [Abstract] [Full Text]  
  • Gasper-Smith, N., Crossman, D. M., Whitesides, J. F., Mensali, N., Ottinger, J. S., Plonk, S. G., Moody, M. A., Ferrari, G., Weinhold, K. J., Miller, S. E., Reich, C. F. III, Qin, L., Self, S. G., Shaw, G. M., Denny, T. N., Jones, L. E., Pisetsky, D. S., Haynes, B. F. (2008). Induction of Plasma (TRAIL), TNFR-2, Fas Ligand, and Plasma Microparticles after Human Immunodeficiency Virus Type 1 (HIV-1) Transmission: Implications for HIV-1 Vaccine Design. J. Virol. 82: 7700-7710 [Abstract] [Full Text]  
  • Mohan, M., Aye, P. P., Borda, J. T., Alvarez, X., Lackner, A. A. (2008). CCAAT/Enhancer Binding Protein {beta} Is a Major Mediator of Inflammation and Viral Replication in the Gastrointestinal Tract of Simian Immunodeficiency Virus-Infected Rhesus Macaques. Am. J. Pathol. 173: 106-118 [Abstract] [Full Text]  
  • Diop, O. M., Ploquin, M. J.-Y., Mortara, L., Faye, A., Jacquelin, B., Kunkel, D., Lebon, P., Butor, C., Hosmalin, A., Barre-Sinoussi, F., Muller-Trutwin, M. C. (2008). Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome. J. Virol. 82: 5145-5152 [Abstract] [Full Text]  
  • Verhoeven, D., Sankaran, S., Silvey, M., Dandekar, S. (2008). Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4+ T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells. J. Virol. 82: 4016-4027 [Abstract] [Full Text]  
  • Carroll, T. D., Matzinger, S. R., Genesca, M., Fritts, L., Colon, R., McChesney, M. B., Miller, C. J. (2008). Interferon-Induced Expression of MxA in the Respiratory Tract of Rhesus Macaques Is Suppressed by Influenza Virus Replication. J. Immunol. 180: 2385-2395 [Abstract] [Full Text]  
  • Brown, S. A., Hurwitz, J. L., Zirkel, A., Surman, S., Takimoto, T., Alymova, I., Coleclough, C., Portner, A., Doherty, P. C., Slobod, K. S. (2007). A Recombinant Sendai Virus Is Controlled by CD4+ Effector T Cells Responding to a Secreted Human Immunodeficiency Virus Type 1 Envelope Glycoprotein. J. Virol. 81: 12535-12542 [Abstract] [Full Text]  
  • Milush, J. M., Stefano-Cole, K., Schmidt, K., Durudas, A., Pandrea, I., Sodora, D. L. (2007). Mucosal Innate Immune Response Associated with a Timely Humoral Immune Response and Slower Disease Progression after Oral Transmission of Simian Immunodeficiency Virus to Rhesus Macaques. J. Virol. 81: 6175-6186 [Abstract] [Full Text]  
  • Hosmalin, A., Lebon, P. (2006). Type I interferon production in HIV-infected patients. J. Leukoc. Biol. 80: 984-993 [Abstract] [Full Text]  
  • Abel, K., Pahar, B., Van Rompay, K. K. A., Fritts, L., Sin, C., Schmidt, K., Colon, R., McChesney, M., Marthas, M. L. (2006). Rapid virus dissemination in infant macaques after oral simian immunodeficiency virus exposure in the presence of local innate immune responses.. J. Virol. 80: 6357-6367 [Abstract] [Full Text]  
  • Li, B., Decker, J. M., Johnson, R. W., Bibollet-Ruche, F., Wei, X., Mulenga, J., Allen, S., Hunter, E., Hahn, B. H., Shaw, G. M., Blackwell, J. L., Derdeyn, C. A. (2006). Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1.. J. Virol. 80: 5211-5218 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»