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Journal of Virology, September 2005, p. 12117-12121, Vol. 79, No. 18
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.18.12117-12121.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans

Oscar Norbeck,1* Adiba Isa,1 Christoph Pöhlmann,2 Kristina Broliden,1 Victoria Kasprowicz,3 Paul Bowness,3 Paul Klenerman,4 and Thomas Tolfvenstam1,2

Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden,1 Division of Clinical Virology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden,2 MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom,3 Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom4

Received 9 June 2005/ Accepted 24 June 2005

Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.

* Corresponding author. Mailing address: Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08:03, SE-17177 Stockholm, Sweden. Phone: 46-8-517 700 00. Fax: 46-8-313147. E-mail: oscar.norbeck{at}cmm.ki.se.

Journal of Virology, September 2005, p. 12117-12121, Vol. 79, No. 18
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.18.12117-12121.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wodarz, D., Sierro, S., Klenerman, P. (2007). Dynamics of killer T cell inflation in viral infections. J R Soc Interface 4: 533-543 [Abstract] [Full Text]  


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