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Journal of Virology, September 2005, p. 12112-12116, Vol. 79, No. 18
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.18.12112-12116.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation

Robert Thimme,1 Victor Appay,2 Marie Koschella,3 Elisabeth Panther,1 Evelyn Roth,3 Andrew D. Hislop,4 Alan B. Rickinson,4 Sarah L. Rowland-Jones,2 Hubert E. Blum,1 and Hanspeter Pircher3*

Institute for Medical Microbiology and Hygiene, Department of Immunology, University Hospital Freiburg, Freiburg, Germany,3 Department of Medicine II, University Hospital Freiburg, Freiburg, Germany,1 MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom,2 CRUK Institute for Cancer Studies, The University of Birmingham, Birmingham, United Kingdom4

Received 11 May 2005/ Accepted 1 July 2005

The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Hygiene, Department of Immunology, Hermann-Herder-Str. 11, University of Freiburg, D-79104 Freiburg, Germany. Phone: 49 761 203 6521. Fax: 49 761 203 6577. E-mail: hanspeter.pircher{at}uniklinik-freiburg.de.

Journal of Virology, September 2005, p. 12112-12116, Vol. 79, No. 18
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.18.12112-12116.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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