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Journal of Virology, September 2005, p. 11529-11532, Vol. 79, No. 17
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.17.11529-11532.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Reversion In Vivo after Inoculation of a Molecular Proviral DNA Clone of Simian Immunodeficiency Virus with a Cytotoxic-T-Lymphocyte Escape Mutation

Masahiro Kobayashi,1 Hiroko Igarashi,1 Akiko Takeda,1 Moriaki Kato,1,2 and Tetsuro Matano1,3*

Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan,1 Department of Urology, School of Medicine, The University of Kyorin, Tokyo 181-8611, Japan,2 AIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan3

Received 2 April 2005/ Accepted 1 June 2005

Vaccine-based control of the replication of a simian immunodeficiency virus (SIV), SIVmac239, in macaques has recently been shown. In the process of the control, a mutant virus escaping from epitope-specific cytotoxic-T-lymphocyte (CTL) responses was rapidly selected and contained. In this study, we show that the wild-type virus appeared and became predominant in the absence of the epitope-specific CTL after inoculation of naive macaques with a molecular clone DNA of the CTL escape mutant SIV. This is the first report describing reversion in vivo from an inoculated, molecular proviral DNA clone of immunodeficiency virus with a CTL escape mutation.

* Corresponding author. Mailing address: Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Phone: 81-3-5841-3407. Fax: 81-3-5841-3374. E-mail: matano{at}m.u-tokyo.ac.jp.

Journal of Virology, September 2005, p. 11529-11532, Vol. 79, No. 17
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.17.11529-11532.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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