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Journal of Virology, August 2005, p. 10069-10072, Vol. 79, No. 15
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.15.10069-10072.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Reduced Prevalence of Epstein-Barr Virus-Related Lymphocryptovirus Infection in Sera from a New World Primate

Mark H. Fogg,1 Angela Carville,2 Jennifer Cameron,1 Carol Quink,1 and Fred Wang1*

Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,1 Department of Primate Resources, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 017722

Received 6 January 2005/ Accepted 3 May 2005

The recent discovery of an Epstein-Barr virus (EBV)-related lymphocryptovirus (LCV) naturally infecting common marmosets demonstrated that gamma-1 herpesviruses are not limited to human and Old World nonhuman primate hosts. We developed serologic assays to detect serum antibodies against lytic- and latent-infection marmoset LCV antigens in order to perform the first seroepidemiologic study of LCV infection in New World primates. In three different domestic colonies and in animals recently captured from the wild, we found that the seroprevalence of marmoset LCV infection was not as ubiquitous as with EBV or Old World LCV. These biologic differences in LCV infection of New World versus human and Old World primate hosts correlate with the evolution of the LCV viral gene repertoire.

* Corresponding author. Mailing address: Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115. Phone: (617) 525-4258. Fax: (617) 525-4257. E-mail: fwang{at}rics.bwh.harvard.edu.

Journal of Virology, August 2005, p. 10069-10072, Vol. 79, No. 15
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.15.10069-10072.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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