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Journal of Virology, August 2005, p. 10059-10062, Vol. 79, No. 15
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.15.10059-10062.2005

High-Potency Human Immunodeficiency Virus Vaccination Leads to Delayed and Reduced CD8+ T-Cell Expansion but Improved Virus Control

Miles P. Davenport,1 Lei Zhang,1 Ansuman Bagchi,2 Arthur Fridman,2 Tong-Ming Fu,2 William Schleif,2 John W. Shiver,2 Ruy M. Ribeiro,3 and Alan S. Perelson3*

Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia,1 Merck Research Laboratories, West Point, Pennsylvania 19486,2 Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 875453

Received 30 March 2005/ Accepted 12 April 2005

CD8+ T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the first observed increase in virus-specific CD8+ T-cell numbers. Prior to this time, viral kinetics are not significantly different between controls and vaccinees. Surprisingly, higher initial virus-specific CD8+ T-cell numbers lead to a longer delay prior to initial CD8+ T-cell expansion, and slower CD8+ T-cell increases. Nevertheless, higher initial CD8+ T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4+ T-cell depletion.

* Corresponding author. Mailing address: Los Alamos National Laboratory, Theoretical Biology and Biophysics, MS K710, Los Alamos, NM 87545. Phone: (505) 667-6829. Fax: (505) 665-3493. E-mail: asp{at}lanl.gov.

Journal of Virology, August 2005, p. 10059-10062, Vol. 79, No. 15
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.15.10059-10062.2005




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