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 Previous Article

Journal of Virology, July 2005, p. 9363-9366, Vol. 79, No. 14
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.14.9363-9366.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Intrapatient Escape in the A*0201-Restricted Epitope SLYNTVATL Drives Evolution of Human Immunodeficiency Virus Type 1 at the Population Level

Charles T. T. Edwards,1 Katja J. Pfafferott,1 Philip J. R. Goulder,1 Rodney E. Phillips,1 and Edward C. Holmes2*

Nuffield Department of Clinical Medicine, University of Oxford, The Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY,1 Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom2

Received 29 November 2004/ Accepted 26 March 2005

The hypothesis that the intrapatient emergence of cytotoxic T-lymphocyte escape variants contributes to the evolution of human immunodeficiency virus type 1 at the population (interpatient) level was tested using the HLA-A*0201-restricted gag p17 epitope SLYNTVATL. Using a simple experimental design, we investigated the evolutionary processes operating within this epitope among patients while compensating for the confounding influence of intrapatient natural selection. Using this approach, we revealed a pattern of A*0201-driven escape within patients, followed by the sustained transmission of these escape variants among patients irrespective of their HLA type.

* Corresponding author. Present address: Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802. Phone: (814) 863-4689. Fax: (814) 865-9131. E-mail: ech15{at}psu.edu.

Journal of Virology, July 2005, p. 9363-9366, Vol. 79, No. 14
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.14.9363-9366.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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