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Journal of Virology, July 2005, p. 9320-9324, Vol. 79, No. 14
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.14.9320-9324.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target

Jessica R. Kirshner,{dagger} Alla Y. Karpova,{ddagger} Maren Kops,§ and Peter M. Howley*

Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115

Received 17 March 2005/ Accepted 23 March 2005

Interferon production and apoptosis in virus-infected cells are necessary to prevent progeny virus production and to eliminate infected cells. Paramyxovirus infection induces apoptosis through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is unknown. We show that IRF-3 is involved in the transcriptional induction of TRAIL, a key player in the apoptosis pathway. IRF-3 upregulates TRAIL transcription following viral infection and binds an interferon-stimulated response element in the TRAIL promoter. The mRNA for TRAIL and its receptor, DR5, are induced following viral infection. These studies identify TRAIL as a novel IRF-3 transcriptional target.

* Corresponding author. Mailing address: Department of Pathology, NRB-950, 77 Avenue Louis Pasteur, Boston, MA 02115. Phone: (617) 432-2884. Fax: (617) 432-2882. E-mail: peter_howley{at}hms.harvard.edu.

{dagger} Present address: Synta Pharmaceuticals, 45 Hartwell Ave., Lexington, MA 02421.

{ddagger} Present address: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724.

§ Present address: Meisemweg 15, 52078 Aachen, Germany.

Journal of Virology, July 2005, p. 9320-9324, Vol. 79, No. 14
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.14.9320-9324.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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