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Journal of Virology, July 2005, p. 9306-9314, Vol. 79, No. 14
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.14.9306-9314.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Evidence of Recombination between Divergent Hepatitis E Viruses

Hélène van Cuyck,1 Jun Fan,2 David L. Robertson,2* and Pierre Roques3

Etat Major des Armées, Maîtrise des Armements, Cellule d'analyse des risques biologiques et chimiques, Paris, France,1 Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom,2 Service de Neurovirologie, DSV/DRM CEA, CRSSA, Fontenay aux Roses, France3

Received 10 December 2004/ Accepted 13 March 2005

Phylogenetic and recombination analysis was performed on 32 complete hepatitis E virus (HEV) genomes from infected humans and pigs. For the first time, evidence for recombination between divergent HEV strains was obtained, with at least two strains being found to have discordant phylogenetic relationships consistent with the occurrence of intragenotype recombination. This finding confirms that humans can be dually infected with divergent HEV strains and has implications for the emergence and evolution of new HEV epidemics.

* Corresponding author. Mailing address: Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom. Phone: 44 (0)161 275 5089. Fax: 44 (0)161 275 5082. E-mail: david.robertson{at}manchester.ac.uk.

Journal of Virology, July 2005, p. 9306-9314, Vol. 79, No. 14
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.14.9306-9314.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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Copyright © 2005 by the American Society for Microbiology. All rights reserved.