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Journal of Virology, July 2005, p. 8243-8248, Vol. 79, No. 13
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.13.8243-8248.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Avian Sarcoma and Leukosis Virus Cytopathic Effect in the Absence of TVB Death Domain Signaling

Sara Klucking,1 Asha S. Collins,2 and John A. T. Young3*

Emory Vaccine Center, Emory University, 954 Gatewood Road, Atlanta, Georgia 30322,1 McArdle Laboratory for Cancer Research, University of Wisconsin—Madison, 1400 University Avenue, Madison, Wisconsin 53706,2 The Salk Institute for Biological Studies, Infectious Disease Laboratory, 10010 North Torrey Pines Road, La Jolla, California 920373

Received 19 September 2003/ Accepted 6 March 2005

The cytopathic effect (CPE) seen with some subgroups of avian sarcoma and leukosis virus (ASLV) is associated with viral Env activation of the death-promoting activity of TVB (a tumor necrosis factor receptor-related receptor that is most closely related to mammalian TNF-related apoptosis-inducing ligand [TRAIL] receptors) and with viral superinfection leading to unintegrated viral DNA (UVD) accumulation, which is presumed to activate a cellular DNA damage response. In this study, we employed cells that express signaling-deficient ASLV receptors to demonstrate that an ASLV CPE can be uncoupled from the death-promoting functions of the TVB receptor. However, these cell-killing events were associated with much higher levels of viral superinfection and DNA accumulation than those seen when the virus used signaling-competent TVB receptors. These findings suggest that a putative cellular DNA damage response that is activated by UVD accumulation might act in concert with the death-signaling pathways activated by Env-TVB interactions to trigger cell death. Such a model is consistent with the well-established synergy that exists between TRAIL-signaling pathways and DNA damage responses which is currently being exploited in cancer therapy regimens.

* Corresponding author. Mailing address: The Salk Institute for Biological Studies, Infectious Disease Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037. Phone: (858) 453-4100, ext. 1903. Fax: (608) 262-2824. E-mail: jyoung{at}salk.edu.

Journal of Virology, July 2005, p. 8243-8248, Vol. 79, No. 13
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.13.8243-8248.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Rainey, G. J. A., Coffin, J. M. (2006). Evolution of Broad Host Range in Retroviruses Leads to Cell Death Mediated by Highly Cytopathic Variants. J. Virol. 80: 562-570 [Abstract] [Full Text]  


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