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Journal of Virology, June 2005, p. 7889-7898, Vol. 79, No. 12
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.12.7889-7898.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Complementation of Human Papillomavirus Type 16 E6 and E7 by Jagged1-Specific Notch1-Phosphatidylinositol 3-Kinase Signaling Involves Pleiotropic Oncogenic Functions Independent of CBF1;Su(H);Lag-1 Activation{dagger}

Karthikeyan Veeraraghavalu, Vanitha K. Subbaiah, Sweta Srivastava, Oishee Chakrabarti, Ruchi Syal, and Sudhir Krishna*

National Centre for Biological Sciences, TIFR, UAS-GKVK Campus, Bangalore 560065, India

Received 14 September 2004/ Accepted 14 February 2005

We have analyzed the induction and role of phosphatidylinositol 3-kinase (PI3K) by Notch signaling in human papillomavirus (HPV)-derived cancers. Jagged1, in contrast to Delta1, is preferentially upregulated in human cervical tumors. Jagged1 and not Delta1 expression sustained in vivo tumors by HPV16 oncogenes in HaCaT cells. Further, Jagged1 expression correlates with the rapid induction of PI3K-mediated epithelial-mesenchymal transition in both HaCaT cells and a human cervical tumor-derived cell line, suggestive of Delta1;Serrate/Jagged;Lag2 ligand-specific roles. Microarray analysis and dominant-negatives reveal that Notch-PI3K oncogenic functions can be independent of CBF1;Su(H);Lag-1 activation and instead relies on Deltex1, an alternative Notch effector.

* Corresponding author. Mailing address: National Centre for Biological Sciences, TIFR, UAS-GKVK Campus, Bangalore 560065, India. Phone: 011918012636421. Fax: 011918012636421. E-mail: skrishna{at}ncbs.res.in.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org.

Journal of Virology, June 2005, p. 7889-7898, Vol. 79, No. 12
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.12.7889-7898.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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