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Journal of Virology, May 2005, p. 6560-6564, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6560-6564.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Residues in the Murine Leukemia Virus Capsid That Differentially Govern Resistance to Mouse Fv1 and Human Ref1 Restrictions

Adeline Lassaux, Marc Sitbon,* and Jean-Luc Battini*

Institut de Génétique Moléculaire de Montpellier, CNRS UMR5535, IFR122, 1919 Route de Mende, F-34293 Montpellier Cedex 5, France

Received 4 September 2004/ Accepted 18 January 2005

We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1b resistance, whereas the latter is sufficient to confer Ref1 resistance.

* Corresponding author. Mailing address: IGMM, CNRS-UMR5535, IFR122, 1919 Rte de Mende, F-34293 Montpellier Cedex 5, France. Phone: 33 (467) 613 640. Fax: 33 (467) 040 231. E-mail for Marc Sitbon: sitbon{at}igmm.cnrs.fr. E-mail for Jean-Luc Battini: jean-luc.battini{at}igmm.cnrs.fr.

Journal of Virology, May 2005, p. 6560-6564, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6560-6564.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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