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Journal of Virology, May 2005, p. 6551-6553, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6551-6553.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Low Levels of Human Immunodeficiency Virus Type 1 DNA in High-Risk Seronegative Men

Fransje A. Koning, Teun J. K. van der Vorst, and Hanneke Schuitemaker*

Dept. of Clinical Viro Immunology, Sanquin Research at CLB, and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 24 August 2004/ Accepted 16 January 2005

We detected human immunodeficiency virus type 1 (HIV-1) DNA at very low levels in sequential peripheral blood mononuclear cell samples of five out of six high-risk, seronegative, homosexual men and five out of five individuals 7.8 to 1.6 years prior to seroconversion. These data indicate a high prevalence of low-level HIV-1 DNA in exposed seronegative individuals.


* Corresponding author. Mailing address: Sanquin Research at CLB, Dept. of Clinical Viro Immunology, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. Phone: 31-20-5123317. Fax: 31-20-5123310. E-mail: H.Schuitemaker{at}sanquin.nl.


Journal of Virology, May 2005, p. 6551-6553, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6551-6553.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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