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Journal of Virology, May 2005, p. 6523-6527, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6523-6527.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Variation and Neutralizing Antibody Responses during Transmission of HIV-1 Subtype B

Simon D. W. Frost,1* Yang Liu,2 Sergei L. Kosakovsky Pond,1 Colombe Chappey,2 Terri Wrin,2 Christos J. Petropoulos,2 Susan J. Little,1 and Douglas D. Richman1,3

University of California,1 Veterans Affairs San Diego Healthcare System, San Diego,3 ViroLogic, Inc., South San Francisco, California2

Received 8 October 2004/ Accepted 19 February 2005

We analyzed neutralization sensitivity and genetic variation of transmitted subtype B human immunodeficiency virus type 1 (HIV-1) in eight recently infected men who have sex with men and the virus from the six subjects who infected them. In contrast to reports of heterosexual transmission of subtype C HIV-1, in which the transmitted virus appears to be more neutralization sensitive, we demonstrate that in our study population, relatively few phenotypic changes in neutralization sensitivity or genotypic changes in envelope occurred during transmission of subtype B HIV-1. We suggest that limited genetic variation within the infecting host reduces the likelihood of selective transmission of neutralization-sensitive HIV.

* Corresponding author. Mailing address: UCSD Antiviral Research Center, 150 W. Washington St., Suite 100, San Diego, CA 92103. Phone: (619) 543-8080. Fax: (619) 298-0177. E-mail: sdfrost{at}ucsd.edu.

Journal of Virology, May 2005, p. 6523-6527, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6523-6527.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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