This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gitiban, N. Articles by Durbin, J. E. Search for Related Content PubMed PubMed Citation Articles by Gitiban, N. Articles by Durbin, J. E.

 Previous Article  |  Next Article 

Journal of Virology, May 2005, p. 6035-6042, Vol. 79, No. 10
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.10.6035-6042.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Chinchilla and Murine Models of Upper Respiratory Tract Infections with Respiratory Syncytial Virus

Negin Gitiban,^2, Joseph A. Jurcisek,^1, Randall H. Harris,^1, Sara E. Mertz,² Russell K. Durbin,² Lauren O. Bakaletz,^1* and Joan E. Durbin²

Columbus Children's Research Institute Center for Microbial Pathogenesis,¹ Center for Vaccines and Immunity and Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, Ohio²

Received 4 August 2004/ Accepted 9 January 2005

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants and the elderly. While the primary infection is the most serious, reinfection of the upper airway throughout life is the rule. Although relatively little is known about either RSV infection of the upper respiratory tract or host mucosal immunity to RSV, recent literature suggests that RSV is the predominant viral pathogen predisposing to bacterial otitis media (OM). Herein, we describe mouse and chinchilla models of RSV infection of the nasopharynx and Eustachian tube. Both rodent hosts were susceptible to RSV infection of the upper airway following intranasal challenge; however, the chinchilla proved to be more permissive than the mouse. The chinchilla model will likely be extremely useful to test the role of RSV in bacterial OM and the efficacy of RSV vaccine candidates designed to provide mucosal and cytotoxic T-lymphocyte immunity. Ultimately, we hope to investigate the relative ability of these candidates to potentially protect against viral predisposal to bacterial OM.

These authors contributed equally to this work.

Present address: Claflin University, Department of Biology, Orangeburg, S.C.

This article has been cited by other articles:

• Novotny, L. A., Partida-Sanchez, S., Munson, R. S. Jr., Bakaletz, L. O. (2008). Differential Uptake and Processing of a Haemophilus influenzae P5-Derived Immunogen by Chinchilla Dendritic Cells. Infect. Immun. 76: 967-977 [Abstract] [Full Text]  
• Avadhanula, V., Rodriguez, C. A., DeVincenzo, J. P., Wang, Y., Webby, R. J., Ulett, G. C., Adderson, E. E. (2006). Respiratory Viruses Augment the Adhesion of Bacterial Pathogens to Respiratory Epithelium in a Viral Species- and Cell Type-Dependent Manner. J. Virol. 80: 1629-1636 [Abstract] [Full Text]