This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milstone, A. M.
Right arrow Articles by Bergelson, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milstone, A. M.
Right arrow Articles by Bergelson, J. M.

 Previous Article  |  Next Article 

Journal of Virology, January 2005, p. 655-660, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.655-660.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interaction with Coxsackievirus and Adenovirus Receptor, but Not with Decay-Accelerating Factor (DAF), Induces A-Particle Formation in a DAF-Binding Coxsackievirus B3 Isolate

Aaron M. Milstone,1 JenniElizabeth Petrella,1 Melissa D. Sanchez,1 Mariam Mahmud,1 J. Charles Whitbeck,2 and Jeffrey M. Bergelson1*

Division of Infectious Diseases, Children's Hospital of Philadelphia,1 Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania2

Received 7 June 2004/ Accepted 11 August 2004

Although many coxsackie B viruses interact with decay accelerating factor (DAF), attachment to DAF by itself is not sufficient to initiate infection. We examined the early events in infection that follow virus interaction with DAF, and with the coxsackievirus and adenovirus receptor (CAR). Interaction with soluble CAR in a cell-free system, or with CAR on the surfaces of transfected cells, induced the formation of A particles; interaction with soluble or cell surface DAF did not. The results suggest that CAR, but not DAF, is capable of initiating the conformational changes in the viral capsid that lead to release of viral nucleic acid.

* Corresponding author. Mailing address: Abramson 1202, Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104. Phone: (215) 590-3771. Fax: (215) 590-2025. E-mail: bergelson{at}email.chop.edu.

Journal of Virology, January 2005, p. 655-660, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.655-660.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Patel, K. P., Coyne, C. B., Bergelson, J. M. (2009). Dynamin- and Lipid Raft-Dependent Entry of Decay-Accelerating Factor (DAF)-Binding and Non-DAF-Binding Coxsackieviruses into Nonpolarized Cells. J. Virol. 83: 11064-11077 [Abstract] [Full Text]  
  • Martin-Acebes, M. A., Gonzalez-Magaldi, M., Vazquez-Calvo, A., Armas-Portela, R., Sobrino, F. (2009). Internalization of Swine Vesicular Disease Virus into Cultured Cells: a Comparative Study with Foot-and-Mouth Disease Virus. J. Virol. 83: 4216-4226 [Abstract] [Full Text]  
  • Shi, Y., Chen, C., Lisewski, U., Wrackmeyer, U., Radke, M., Westermann, D., Sauter, M., Tschope, C., Poller, W., Klingel, K., Gotthardt, M. (2009). Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.. J Am Coll Cardiol 53: 1219-1226 [Abstract] [Full Text]  
  • Hafenstein, S., Bowman, V. D., Chipman, P. R., Kelly, C. M. B., Lin, F., Medof, M. E., Rossmann, M. G. (2007). Interaction of Decay-Accelerating Factor with Coxsackievirus B3. J. Virol. 81: 12927-12935 [Abstract] [Full Text]  
  • Lim, B.-K., Choi, J.-H., Nam, J.-H., Gil, C.-O., Shin, J.-O., Yun, S.-H., Kim, D.-K., Jeon, E.-S. (2006). Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis. Cardiovasc Res 71: 517-526 [Abstract] [Full Text]  
  • Goodfellow, I. G., Evans, D. J., Blom, A. M., Kerrigan, D., Miners, J. S., Morgan, B. P., Spiller, O. B. (2005). Inhibition of Coxsackie B Virus Infection by Soluble Forms of Its Receptors: Binding Affinities, Altered Particle Formation, and Competition with Cellular Receptors. J. Virol. 79: 12016-12024 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»