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Journal of Virology, January 2005, p. 644-648, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.644-648.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Ubiquitin-Proteasome System Facilitates the Transfer of Murine Coronavirus from Endosome to Cytoplasm during Virus Entry

Guann-Yi Yu and Michael M. C. Lai*

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California

Received 30 April 2004/ Accepted 16 August 2004

The ubiquitin-proteasome system is involved in cellular endocytosis and maturation of some viruses. In this study, we found that proteasome inhibitors blocked mouse hepatitis virus replication at an early step in the viral life cycle. In the presence of MG132, the entering viruses accumulated in both the endosome and denser lysosome, suggesting that the ubiquitin-proteasome system is involved in the release of virus from the endosome to the cytosol during the virus entry step.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Ave., Los Angeles, CA 90033-1054. Phone: (323) 442-1748. Fax: (323) 442-1721. E-mail: michlai{at}hsc.usc.edu.

Journal of Virology, January 2005, p. 644-648, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.644-648.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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