This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pierce, M. A.
Right arrow Articles by Serreze, D. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pierce, M. A.
Right arrow Articles by Serreze, D. V.

 Previous Article  |  Next Article 

Journal of Virology, January 2005, p. 619-621, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.619-621.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Adenovirus Early Region 3 Transgenes Expressed in ß Cells Prevent Autoimmune Diabetes in Nonobese Diabetic Mice: Effects of Deleting the Adenovirus Death Protein 11.6K

Melissa A. Pierce,1 Anton Svetlanov,2 Marshall S. Horwitz,2 and David V. Serreze1*

The Jackson Laboratory, Bar Harbor, Maine,1 Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York2

Received 29 April 2004/ Accepted 5 August 2004

The incidence of type 1 diabetes (T1D) is decreased in nonobese diabetic mice expressing the complete cassette of adenovirus early region 3 (E3) immunomodulating genes in pancreatic ß cells. Embedded among the antiapoptotic E3 genes is one encoding an adenovirus death protein (ADP), which contributes to release of virion particles by promoting cell lysis. Because removal of this proapoptotic protein might have further enhanced the ability of E3 proteins to prevent T1D, an ADP-inactivated E3 construct was tested. Significantly, deletion of ADP did not improve the diabetes-protective effect of an E3 gene cassette.

* Corresponding author. Mailing address: The Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609. Phone: (207) 288-6403. Fax: (207) 288-6079. E-mail: dvs{at}jax.org.

Journal of Virology, January 2005, p. 619-621, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.619-621.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chin, Y. R., Horwitz, M. S. (2005). Mechanism for Removal of Tumor Necrosis Factor Receptor 1 from the Cell Surface by the Adenovirus RID{alpha}/{beta} Complex. J. Virol. 79: 13606-13617 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»