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Journal of Virology, January 2005, p. 602-608, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.602-608.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Long-Term Productive Human Immunodeficiency Virus Infection of CD1a-Sorted Myeloid Dendritic Cells

Sergei Popov, Agnès-Laurence Chenine, Andreas Gruber, Pei-Lin Li, and Ruth M. Ruprecht*

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts

Received 17 March 2004/ Accepted 1 September 2004

Myeloid, CD1a-sorted dendritic cells (MDC) productively replicated human immunodeficiency virus strains encoding envelope genes of either primary X4R5 or R5 strains for up to 45 days. Cell-free supernatant collected from long-term infected MDC, which had been exposed to an X4R5 virus 45 days earlier, was still infectious when placed over activated T cells. These data imply that DC can act as a persistent reservoir of infectious virus.

* Corresponding author. Mailing address: Dana-Farber Cancer Institute, 44 Binney St., JFB 809, Boston, MA 02115-6084. Phone: (617) 632-3719. Fax: (617) 632-3112. E-mail: ruth_ruprecht{at}dfci.harvard.edu.

Journal of Virology, January 2005, p. 602-608, Vol. 79, No. 1
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.1.602-608.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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