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Journal of Virology, May 2004, p. 4943-4946, Vol. 78, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.9.4943-4946.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Ror{gamma} (Rorc) Is a Common Integration Site in Type B Leukemogenic Virus-Induced T-Cell Lymphomas

Dana R. Broussard, Mary M. Lozano, and Jaquelin P. Dudley*

Section of Microbiology and Molecular Genetics and Institute of Cellular and Molecular Biology, Austin, Texas 78712

Received 24 October 2003/ Accepted 15 December 2003

The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Ror{gamma} locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Ror{gamma} isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression.


* Corresponding author. Mailing address: Section of Microbiology and Molecular Genetics, One University Station A5000, 24th Street and Speedway, ESB 226, Austin, TX 78712-0162. Phone: (512) 471-8415. Fax: (512) 471-7088. E-mail: jdudley{at}uts.cc.utexas.edu.


Journal of Virology, May 2004, p. 4943-4946, Vol. 78, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.9.4943-4946.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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