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Journal of Virology, May 2004, p. 4927-4930, Vol. 78, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.9.4927-4930.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Intraepithelial T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

Hitoshi Nishimura,¹ Toshiki Yajima,¹ Yoshiko Kagimoto,¹ Mutsuhiro Ohata,² Taketo Watase,² Kenji Kishihara,¹ Fumi Goshima,³ Yukihiro Nishiyama,³ and Yasunobu Yoshikai^1*

Division of Host Defense, Medical Institute for Bioregulation, Kyushu University, Fukuoka 812-8582,¹ Laboratory of Host Defense and Germfree Life,² Laboratory of Virology, Research Institute for Disease Mechanism & Control, Nagoya University School of Medicine, Nagoya 466-8550, Japan³

Received 14 October 2003/ Accepted 6 January 2004

Mice depleted of T cells by in vivo administration of anti-TCR monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the T-cell-depleted mice. Mice deficient in the V1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial T cells bearing V1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

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* Corresponding author. Mailing address: Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Phone: 81-92-642-6962. Fax: 81-92-642-6973. E-mail: yoshikai{at}bioreg.kyushu-u.ac.jp.

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Journal of Virology, May 2004, p. 4927-4930, Vol. 78, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.9.4927-4930.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

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