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Journal of Virology, May 2004, p. 4892-4901, Vol. 78, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.9.4892-4901.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Reemerging H5N1 Influenza Viruses in Hong Kong in 2002 Are Highly Pathogenic to Ducks

Katharine M. Sturm-Ramirez,1 Trevor Ellis,2 Barry Bousfield,3 Lucy Bissett,2 Kitman Dyrting,2 Jerold E. Rehg,4 Leo Poon,5 Yi Guan,5 Malik Peiris,5 and Robert G. Webster1,6*

Division of Virology, Department of Infectious Diseases,1 Department of Pathology, St. Jude Children's Research Hospital,4 Department of Pathology, University of Tennessee Memphis, Tennessee,6 Department of Agriculture, Fisheries and Conservation, Tai Lung Veterinary Laboratory,2 Veterinary Section, Leisure and Cultural Service Department, Hong Kong Zoological and Botanical Gardens,3 Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China5

Received 28 August 2003/ Accepted 29 December 2003

Waterfowl are the natural reservoir of all influenza A viruses, which are usually nonpathogenic in wild aquatic birds. However, in late 2002, outbreaks of highly pathogenic H5N1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two Hong Kong parks. In February 2003, an avian H5N1 virus closely related to one of these viruses was isolated from two humans with acute respiratory distress, one of whom died. Antigenic analysis of the new avian isolates showed a reactivity pattern different from that of H5N1 viruses isolated in 1997 and 2001. This finding suggests that significant antigenic variation has recently occurred among H5N1 viruses. We inoculated mallards with antigenically different H5N1 influenza viruses isolated between 1997 and 2003. The new 2002 avian isolates caused systemic infection in the ducks, with high virus titers and pathology in multiple organs, particularly the brain. Ducks developed acute disease, including severe neurological dysfunction and death. Virus was also isolated at high titers from the birds' drinking water and from contact birds, demonstrating efficient transmission. In contrast, H5N1 isolates from 1997 and 2001 were not consistently transmitted efficiently among ducks and did not cause significant disease. Despite a high level of genomic homology, the human isolate showed striking biological differences from its avian homologue in a duck model. This is the first reported case of lethal influenza virus infection in wild aquatic birds since 1961.

* Corresponding author. Mailing address: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794. Phone: (901) 495-3400. Fax: (901) 523-2622. E-mail: robert.webster{at}stjude.org.

Journal of Virology, May 2004, p. 4892-4901, Vol. 78, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.9.4892-4901.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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