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Journal of Virology, April 2004, p. 4357-4362, Vol. 78, No. 8
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.8.4357-4362.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Leader Protein of Theiler's Virus Interferes with Nucleocytoplasmic Trafficking of Cellular Proteins

Sophie Delhaye, Vincent van Pesch, and Thomas Michiels*

Christian de Duve Institute of Cellular Pathology, University of Louvain, MIPA-VIRO 74-49, B-1200 Brussels, Belgium

Received 16 July 2003/ Accepted 23 December 2003

The leader protein of Theiler's virus was previously shown to block the production of alpha/beta interferon by infected cells. Here, we observed that expression of the leader protein in infected cells triggered subcellular redistribution of a nucleus-target green fluorescent protein. It enhanced redistribution of the nuclear polypyrimidine tract-binding protein but had no influence on the localization of the nuclear splicing factor SC-35. The leader protein also interfered with trafficking of the cytoplasmic interferon regulatory factor 3, a factor critical for transcriptional activation of alpha/beta interferon genes.

* Corresponding author. Mailing address: Christian de Duve Institute of Cellular Pathology, University of Louvain, MIPA-VIRO 74-49, 74, avenue Hippocrate, B-1200 Brussels, Belgium. Phone: 32 2 764 74 29. Fax: 32 2 764 74 95. E-mail: michiels{at}mipa.ucl.ac.be.

Journal of Virology, April 2004, p. 4357-4362, Vol. 78, No. 8
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.8.4357-4362.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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