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Journal of Virology, April 2004, p. 3846-3850, Vol. 78, No. 8
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.8.3846-3850.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Interplay between Alpha/Beta and Gamma Interferons with B, T, and Natural Killer Cells in the Defense against Herpes Simplex Virus Type 1

Sabine Vollstedt,1 Susi Arnold,2 Cornelia Schwerdel,1 Marco Franchini,1 Gottfried Alber,3 James P. Di Santo,4 Mathias Ackermann,1 and Mark Suter1*

Institute of Virology,1 Gynecology Department, University of Zurich, Zurich, Switzerland,2 Institute of Immunology, University of Leipzig, Leipzig, Germany,3 Immunology Department, Pasteur Institute, Paris, France4

Received 10 September 2003/ Accepted 23 December 2003

The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-{alpha}/ß) alone without significant contribution of B, T, or NK cells. IFN-{alpha}/ß and IFN-{gamma} cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.

* Corresponding author. Mailing address: Institute of Virology, University of Zurich, Winterthurerstr. 266a, CH-8057 Zurich, Switzerland. Phone: 41 1 635 87 17. Fax: 41 1 635 89 11. E-mail: msuter{at}vetvir.unizh.ch.

Journal of Virology, April 2004, p. 3846-3850, Vol. 78, No. 8
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.8.3846-3850.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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