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Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication

Department of Public Health and Microbiology, University of Torino, Turin, Italy,¹ Serono International, Geneva, Switzerland²

Received 31 July 2003/ Accepted 25 November 2003

Human cytomegalovirus (HCMV) exploits the host transcription factor NF-B to enhance its own replication, dissemination, and reactivation from latency. Here we report that HCMV infection activates the upstream IB kinase (IKK) complex and that its catalytic IKK2 subunit is required for HCMV-induced NF-B activation, as well as the replication of different HCMV strains. These results indicate that IKK2 is essential for HCMV replication and emphasize the feasibility of blocking NF-B activation as a way of inhibiting infection.

This paper is dedicated to the memory of Giorgio Cavallo.

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