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Journal of Virology, March 2004, p. 3190-3195, Vol. 78, No. 6
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.6.3190-3195.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication{dagger}

Patrizia Caposio,1 Michel Dreano,2 Gianni Garotta,2 Giorgio Gribaudo,1* and Santo Landolfo1

Department of Public Health and Microbiology, University of Torino, Turin, Italy,1 Serono International, Geneva, Switzerland2

Received 31 July 2003/ Accepted 25 November 2003

Human cytomegalovirus (HCMV) exploits the host transcription factor NF-{kappa}B to enhance its own replication, dissemination, and reactivation from latency. Here we report that HCMV infection activates the upstream I{kappa}B kinase (IKK) complex and that its catalytic IKK2 subunit is required for HCMV-induced NF-{kappa}B activation, as well as the replication of different HCMV strains. These results indicate that IKK2 is essential for HCMV replication and emphasize the feasibility of blocking NF-{kappa}B activation as a way of inhibiting infection.

* Corresponding author. Mailing address: Department of Public Health and Microbiology, University of Torino, Via Santena, 9-10126 Turin, Italy. Phone: 39.011.6706623. Fax: 39.011.6636436. E-mail: giorgio.gribaudo{at}unito.it.

{dagger} This paper is dedicated to the memory of Giorgio Cavallo.

Journal of Virology, March 2004, p. 3190-3195, Vol. 78, No. 6
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.6.3190-3195.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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