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Journal of Virology, March 2004, p. 2632-2636, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2632-2636.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections

O. Adams,1 K. Besken,2 C. Oberdörfer,2 C. R. MacKenzie,2 O. Takikawa,3 and W. Däubener2*

Institut für Virologie,1 Institut für Medizinische Mikrobiologie, Heinrich-Heine-Universität, D-40225 Dusseldorf, Germany,2 Department of Cell Pharmacology, Hokkaido University, Sapporo 060-8638, Japan3

Received 8 July 2003/ Accepted 12 November 2003

Gamma interferon (IFN-{gamma})-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts of L-tryptophan. Both IFN-{alpha} and IFN-ß restricted herpes simplex virus replication in both cell types, but (in contrast to the results seen with IFN-{gamma}) the addition of an excess amount of L-tryptophan did not inhibit the induced antiviral effect.

* Corresponding author. Mailing address: Institute for Medical Microbiology, Universitätsstrasse 1 Geb. 22.21, 40225 Düsseldorf, Germany. Phone: 49-211-81-12464. Fax: 49-211-81-15323. E-mail: daeubene{at}uni-duesseldorf.de.

Journal of Virology, March 2004, p. 2632-2636, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2632-2636.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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