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Journal of Virology, March 2004, p. 2606-2608, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2606-2608.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Cryoelectron Microscopy of Mouse Mammary Tumor Virus

John A. G. Briggs, Barbara E. Watson, Brent E. Gowen,{dagger} and Stephen D. Fuller*

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom

Received 26 August 2003/ Accepted 14 November 2003

Cryoelectron microscopy of Mouse mammary tumor virus, a Betaretrovirus, provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses. Betaretroviruses assemble cytoplasmically, so the broad size range cannot reflect the use of the plasma membrane as a platform for assembly.

* Corresponding author. Mailing address: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom. Phone: 44 1865 287708. Fax: 44 1865 287547. E-mail: stephen.fuller{at}strubi.ox.ac.uk.

{dagger} Present address: Department of Biology, University of Victoria, Victoria, British Columbia V8W 3N5, Canada.

Journal of Virology, March 2004, p. 2606-2608, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2606-2608.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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