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Journal of Virology, March 2004, p. 2597-2600, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2597-2600.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Specific Interaction of Feline Immunodeficiency Virus Surface Glycoprotein with Human DC-SIGN

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037,¹ Department of Microbiology, Immunology & Molecular Genetics, UCLA School of Medicine and UCLA AIDS Institute, Los Angeles, California 90095²

Received 5 November 2002/ Accepted 27 October 2003

DC-SIGN, a specific C-type lectin expressed on dendritic cells, binds and transmits multiple strains of primate immunodeficiency viruses to susceptible cells. Here, we report that human DC-SIGN also captures feline immunodeficiency virus via high-affinity (1 nM), Ca²⁺-dependent, D-mannose-inhibited binding to the major envelope glycoprotein, gp95.

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