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Journal of Virology, March 2004, p. 2591-2596, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2591-2596.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inflammatory Cytokines Inhibit Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Transcription in In Vitro-Infected Endothelial Cells

Steven Milligan, Mairi Robinson, Elizabeth O'Donnell, and David J. Blackbourn*

Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, United Kingdom

Received 11 April 2003/ Accepted 7 November 2003

The response of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) to inflammatory cytokine treatment of experimentally infected endothelial cells was investigated. The cytokines inhibited spontaneous KSHV lytic gene expression but not the level of infection. The data suggest that if inflammatory cytokines present in KS lesions contribute to KSHV pathogenesis, they do so in part by promoting latent KSHV infection of the endothelial cells.

* Corresponding author. Mailing address: Institute of Virology, University of Glasgow, Church St., Glasgow G11 5JR, United Kingdom. Phone: 44 (0)141 330 3685. Fax: 44 (0)141 337 2236. E-mail: d.blackbourn{at}vir.gla.ac.uk.

Journal of Virology, March 2004, p. 2591-2596, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2591-2596.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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