This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McKenna, P. M. Articles by Schnell, M. J. Search for Related Content PubMed PubMed Citation Articles by McKenna, P. M. Articles by Schnell, M. J.

Immunogenicity Study of Glycoprotein-Deficient Rabies Virus Expressing Simian/Human Immunodeficiency Virus SHIV_89.6P Envelope in a Rhesus Macaque

Departments of Microbiology,¹ Biochemistry and Molecular Pharmacology,⁴ Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania,⁵ Tulane National Primate Research Center, Covington, Louisiana,² Department of Surgery, Duke University, Durham, North Carolina³

Received 19 May 2004/ Accepted 4 August 2004

Rabies virus (RV) has recently been developed as a novel vaccine candidate for human immunodeficiency virus type 1 (HIV-1). The RV glycoprotein (G) can be functionally replaced by HIV-1 envelope glycoprotein (Env) if the gp160 cytoplasmic domain (CD) of HIV-1 Env is replaced by that of RV G. Here, we describe a pilot study of the in vivo replication and immunogenicity of an RV with a deletion of G (G) expressing a simian/human immunodeficiency virus SHIV_89.6P Env ectodomain and transmembrane domain fused to the RV G CD (G-89.6P-RVG) in a rhesus macaque. An animal vaccinated with G-89.6P-RVG developed SHIV_89.6P virus-neutralizing antibodies and SHIV_89.6P-specific cellular immune responses after challenge with SHIV_89.6P. There was no evidence of CD4⁺ T-cell loss, and plasma viremia was controlled to undetectable levels by 6 weeks postchallenge and has remained suppressed out to 22 weeks postchallenge.

This article has been cited by other articles:

• Li, Y., Cleveland, B., Klots, I., Travis, B., Richardson, B. A., Anderson, D., Montefiori, D., Polacino, P., Hu, S.-L. (2008). Removal of a Single N-Linked Glycan in Human Immunodeficiency Virus Type 1 gp120 Results in an Enhanced Ability To Induce Neutralizing Antibody Responses. J. Virol. 82: 638-651 [Abstract] [Full Text]