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Journal of Virology, December 2004, p. 13391-13394, Vol. 78, No. 23
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.23.13391-13394.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

RNA Degradation Induced by the Herpes Simplex Virus vhs Protein Proceeds 5' to 3' In Vitro

Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada

Received 8 June 2004/ Accepted 23 September 2004

The herpes simplex virus virion host shutoff protein (vhs) is an mRNA-specific RNase that contributes to shutoff of host protein synthesis. We show here that vhs-induced mRNA decay proceeds 5' to 3' in an in vitro assay system derived from rabbit reticulocyte lysate.

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