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Journal of Virology, December 2004, p. 13356-13361, Vol. 78, No. 23
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.23.13356-13361.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Infection of Macrophage Primary Cultures by Persistent and Nonpersistent Strains of Theiler's Virus: Role of Capsid and Noncapsid Viral Determinants

Ignacio Mena,{dagger} Jean-Pierre Roussarie, and Michel Brahic*

Unité des Virus Lents, CNRS URA 1330, Institut Pasteur, Paris, France

Received 5 December 2003/ Accepted 16 August 2004

We compared the infection of bone marrow macrophages by the DA and GDVII strains of Theiler's virus and by two viruses constructed by exchanging the DA and GDVII capsids. The replication of the GDVII strain and of both chimeric viruses was restricted in macrophages. Therefore, the infection of macrophages requires both capsid and noncapsid viral determinants.

* Corresponding author. Mailing address: Unité des Virus Lents, CNRS URA 1930, Département de Virologie, Institut Pasteur, 75724 Paris Cedex 15, France. Phone: 331-45688867. Fax: 331-140613167. E-mail: mbrahic{at}pasteur.fr.

{dagger} Present address: Departamento de Biotecnologia, INIA, 28040 Madrid, Spain.

Journal of Virology, December 2004, p. 13356-13361, Vol. 78, No. 23
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.23.13356-13361.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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