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Journal of Virology, November 2004, p. 12090-12095, Vol. 78, No. 21
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.21.12090-12095.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus

Andrea Marzi,1,2,{dagger} Thomas Gramberg,1,2,{dagger} Graham Simmons,3,{dagger} Peggy Möller,4 Andrew J. Rennekamp,3 Mandy Krumbiegel,1,2 Martina Geier,1,2 Jutta Eisemann,5 Nadine Turza,5 Bertrand Saunier,6 Alexander Steinkasserer,5 Stephan Becker,4 Paul Bates,3 Heike Hofmann,1,2 and Stefan Pöhlmann1,2*

Institute for Clinical and Molecular Virology,1 Nikolaus-Fiebiger-Center,2 Department of Dermatology, University of Erlangen-Nürnberg, Erlangen,5 Institute for Virology, Philipps-University Marburg, Marburg, Germany,4 Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania,3 Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, Athens, Ohio6

Received 8 March 2004/ Accepted 24 June 2004

The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.

* Corresponding author. Mailing address: University Erlangen-Nürnberg, Nikolaus-Fiebiger-Center, Glückstrasse 6, D-91054 Erlangen, Germany. Phone: 49 9131 8529142. Fax: 49 9131 8529111. E-mail: stefan.poehlmann{at}viro.med.uni-erlangen.de.

{dagger} A.M., T.G., and G.S. contributed equally to this work.

Journal of Virology, November 2004, p. 12090-12095, Vol. 78, No. 21
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.21.12090-12095.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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