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Journal of Virology, November 2004, p. 11778-11785, Vol. 78, No. 21
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.21.11778-11785.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The C-Mer Gene Is Induced by Epstein-Barr Virus Immediate-Early Protein BRLF1

UNC Lineberger Comprehensive Cancer Center,¹ Dental School,² Department of Microbiology and Immunology,³ Department of Medicine,⁴ Department of Pharmacology, University of North Carolina at Chapel Hill, North Carolina⁵

Received 23 February 2004/ Accepted 8 June 2004

BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces expression of the cellular C-mer gene in a variety of cell lines. C-mer expression was detected in lymphoblastoid cells immortalized with wild-type EBV but not in lymphoblastoid cells immortalized with an EBV that had BRLF1 deleted. Oral hairy leukoplakia tongue tissue, which contains the lytic form of EBV replication, also has enhanced C-mer expression. C-mer is a receptor tyrosine kinase activated by the ligand Gas6. C-mer is required for phagocytosis of apoptotic debris by monocytes/macrophages and retinal pigment epithelial cells and is capable of producing an antiapoptotic signal. Modulation of the C-mer signal transduction cascade by a variety of different approaches did not alter the ability of R to induce lytic EBV gene transcription. Therefore, C-mer activation may be important for some other aspect of lytic EBV infection.

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