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Journal of Virology, October 2004, p. 11416-11421, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11416-11421.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Resolution of Primary Severe Acute Respiratory Syndrome-Associated Coronavirus Infection Requires Stat1

Robert J. Hogan,1 Guangping Gao,2 Thomas Rowe,1 Peter Bell,2 Douglas Flieder,3 Jason Paragas,4 Gary P. Kobinger,2 Nelson A. Wivel,2 Ronald G. Crystal,5 Julie Boyer,5 Heinz Feldmann,6 Thomas G. Voss,1 and James M. Wilson2*

Department of Homeland Security, Southern Research Institute, Birmingham, Alabama,1 Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,2 Department of Pathology,3 Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York,5 United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland,4 Department of Medical Microbiology, University of Manitoba and National Microbiology Laboratory, Winnipeg, Canada6

Received 2 April 2004/ Accepted 28 May 2004

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

* Corresponding author. Mailing address: 204 Wistar, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-0819. Fax: (215) 898-6588. E-mail: wilsonjm{at}mail.med.upenn.edu.

Journal of Virology, October 2004, p. 11416-11421, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11416-11421.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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