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Journal of Virology, October 2004, p. 11411-11415, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11411-11415.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Visualization by Live-Cell Microscopy of Disruption of ND10 during Herpes Simplex Virus Type 1 Infection{dagger}

Roger D. Everett* and Alexandros Zafiropoulos{ddagger}

Medical Research Council Virology Unit, University of Glasgow, Glasgow, United Kingdom

Received 3 April 2004/ Accepted 1 June 2004

ND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.

* Corresponding author. Mailing address: MRC Virology Unit, Church St., University of Glasgow, Glasgow G11 5JR, United Kingdom. Phone: 44 141 330 3923. Fax: 44 141 337 2236. E-mail: r.everett{at}vir.gla.ac.uk.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

{ddagger} Present address: Laboratory of Histology, Faculty of Medicine, University of Crete, Heraklion 71110-GR, Greece.

Journal of Virology, October 2004, p. 11411-11415, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11411-11415.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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