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Journal of Virology, October 2004, p. 11405-11410, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11405-11410.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Persistent Infection with Primate Foamy Virus Type 1 Increases Human Immunodeficiency Virus Type 1 Cell Binding via a Bet-Independent Mechanism

Cecile Schiffer,1 Charles-Henri Lecellier,2 Abdelkrim Mannioui,1,3 Nathalie Felix,1 Elisabeth Nelson,1 Jacqueline Lehmann-Che,4 Marie-Louise Giron,4 Jean Claude Gluckman,1 Ali Saib,4 and Bruno Canque1*

EMI-0013 Institut National de la Santé et de la Recherche Médicale, Université Paris 7, and Laboratoire d'Immunologie Cellulaire et Immunopathologie de l'Ecole Pratique des Hautes Etudes, Institut Universitaire d'Hématologie, Hôpital Saint-Louis,1 CNRS UPR9051, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris,4 Institut de Biologie Moléculaire des Plantes—CNRS, Département de Virologie 12, Strasbourg, France,2 Laboratoire de Biochimie and JFR 3012 Associée à l'Agence Universitaire Francophone (AUPELF-UREF), Faculté des Sciences, Rabat, Morocco3

Received 27 April 2004/ Accepted 25 May 2004

We report that human T cells persistently infected with primate foamy virus type 1 (PFV-1) display an increased capacity to bind human immunodeficiency virus type 1 (HIV-1), resulting in increased cell permissiveness to HIV-1 infection and enhanced cell-to-cell virus transmission. This phenomenon is independent of HIV-1 receptor, CD4, and it is not related to PFV-1 Bet protein expression. Increased virus attachment is specifically inhibited by heparin, indicating that it should be mediated by interactions with heparan sulfate glycosaminoglycans expressed on the target cells. Given that both viruses infect similar animal species, the issue of whether coinfection with primate foamy viruses interferes with the natural course of lentivirus infections in nonhuman primates should be considered.

* Corresponding author. Mailing address: Laboratoire d'Immunologie Cellulaire et Immunopathologie de l'EPHE, EMI-0013, Institut Universitaire d'Hématologie, Centre Hayem, Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris CEDEX 10, France. Phone: 33 1 53 72 24 60. Fax: 33 1 53 72 22 37. E-mail: bruno.canque{at}chu-stlouis.fr.

Journal of Virology, October 2004, p. 11405-11410, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11405-11410.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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