This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guillaume, V.
Right arrow Articles by Wild, T. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guillaume, V.
Right arrow Articles by Wild, T. F.

 Previous Article  |  Next Article 

Journal of Virology, January 2004, p. 834-840, Vol. 78, No. 2
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.2.834-840.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Nipah Virus: Vaccination and Passive Protection Studies in a Hamster Model

V. Guillaume,1 H. Contamin,2 P. Loth,2 M.-C. Georges-Courbot,2 A. Lefeuvre,2 P. Marianneau,2 K. B. Chua,3 S. K. Lam,3 R. Buckland,1 V. Deubel,2 and T. F. Wild1*

INSERM Unite 404,1 UBIVE, Institut Pasteur, CERVI, IFR 128, Lyon, France,2 University of Malaysia, Kuala Lumpur, Malaysia3

Received 8 August 2003/ Accepted 2 October 2003

Nipah virus, a member of the paramyxovirus family, was first isolated and identified in 1999 when the virus crossed the species barrier from fruit bats to pigs and then infected humans, inducing an encephalitis with up to 40% mortality. At present there is no prophylaxis for Nipah virus. We investigated the possibility of vaccination and passive transfer of antibodies as interventions against this disease. We show that both of the Nipah virus glycoproteins (G and F) when expressed as vaccinia virus recombinants induced an immune response in hamsters which protected against a lethal challenge by Nipah virus. Similarly, passive transfer of antibody induced by either of the glycoproteins protected the animals. In both the active and passive immunization studies, however, the challenge virus was capable of hyperimmunizing the vaccinated animals, suggesting that although the virus replicates under these conditions, the immune system can eventually control the infection.

* Corresponding author. Mailing address: INSERM U.404, CERVI, IFR 128, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France. Phone: 33 437 282 392. Fax: 33 437 282 391. E-mail: wild{at}cervi-lyon.inserm.fr.

Journal of Virology, January 2004, p. 834-840, Vol. 78, No. 2
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.2.834-840.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bowden, T. A., Crispin, M., Harvey, D. J., Aricescu, A. R., Grimes, J. M., Jones, E. Y., Stuart, D. I. (2008). Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design. J. Virol. 82: 11628-11636 [Abstract] [Full Text]  
  • Mungall, B. A., Middleton, D., Crameri, G., Bingham, J., Halpin, K., Russell, G., Green, D., McEachern, J., Pritchard, L. I., Eaton, B. T., Wang, L.-F., Bossart, K. N., Broder, C. C. (2006). Feline Model of Acute Nipah Virus Infection and Protection with a Soluble Glycoprotein-Based Subunit Vaccine. J. Virol. 80: 12293-12302 [Abstract] [Full Text]  
  • Guillaume, V., Aslan, H., Ainouze, M., Guerbois, M., Fabian Wild, T., Buckland, R., Langedijk, J. P. M. (2006). Evidence of a Potential Receptor-Binding Site on the Nipah Virus G Protein (NiV-G): Identification of Globular Head Residues with a Role in Fusion Promotion and Their Localization on an NiV-G Structural Model.. J. Virol. 80: 7546-7554 [Abstract] [Full Text]  
  • Weingartl, H. M., Berhane, Y., Caswell, J. L., Loosmore, S., Audonnet, J.-C., Roth, J. A., Czub, M. (2006). Recombinant Nipah Virus Vaccines Protect Pigs against Challenge.. J. Virol. 80: 7929-7938 [Abstract] [Full Text]  
  • Georges-Courbot, M. C., Contamin, H., Faure, C., Loth, P., Baize, S., Leyssen, P., Neyts, J., Deubel, V. (2006). Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection.. Antimicrob. Agents Chemother. 50: 1768-1772 [Abstract] [Full Text]  
  • Guillaume, V., Contamin, H., Loth, P., Grosjean, I., Courbot, M. C. G., Deubel, V., Buckland, R., Wild, T. F. (2006). Antibody Prophylaxis and Therapy against Nipah Virus Infection in Hamsters. J. Virol. 80: 1972-1978 [Abstract] [Full Text]  
  • Snell, N. J. C. (2004). Ribavirin Therapy for Nipah Virus Infection. J. Virol. 78: 10211-10211 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»