JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moniuszko, M.
Right arrow Articles by Franchini, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moniuszko, M.
Right arrow Articles by Franchini, G.

 Previous Article  |  Next Article 

Journal of Virology, September 2004, p. 9740-9749, Vol. 78, No. 18
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.18.9740-9749.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Recombinant Interleukin-7 Induces Proliferation of Naive Macaque CD4+ and CD8+ T Cells In Vivo

Marcin Moniuszko,1,{dagger} Terry Fry,2 Wen-Po Tsai,1 Michel Morre,3 Brigitte Assouline,3 Pierre Cortez,3 Mark G. Lewis,4 Scott Cairns,5 Crystal Mackall,2 and Genoveffa Franchini1*

Animal Models and Retroviral Vaccines Section,1 Immunology Section, Pediatric Oncology Branch, National Cancer Institute,2 Henry Jackson Foundation, Bethesda,5 Bioqual, Rockville, Maryland,4 Cytheris, Vanves, France3

Received 26 March 2004/ Accepted 17 May 2004

Interleukin-7 (IL-7) regulates T-cell homeostasis, and its availability is augmented in lymphopenic hosts. Naive CD8+ T cells transferred to lymphopenic mice acquire a memory-like phenotype, raising the possibility that IL-7 is the biological mediator of this effect. Here, we provide direct evidence that IL-7 induces the acquisition of memory-cell markers not only in CD8+ T cells but also in CD4+ T-cell subsets in immune-competent Indian rhesus macaques. The increase of these memory-like populations was dependent on the dose of the cytokine, and these cells were found in the blood as well as secondary lymphoid organs. Memory-like CD4+ and CD8+ T cells acquired the ability to secrete tumor necrosis factor alpha and, to a lesser extent, gamma interferon following stimulation with a cognate antigen. The phenotypic change observed in naive T cells was promptly reversed after discontinuation of IL-7. Importantly, IL-7 induced cycling of both CD4+ and CD8+ central memory and effector memory T cells, demonstrating its contribution to the maintenance of the entire T-cell pool. Thus, IL-7 may be of benefit in the treatment of iatrogenic or virus-induced T-cell depletion.

* Corresponding author. Mailing address: National Cancer Institute, Bldg. 41, Rm. D804, Bethesda, MD 20892-5065. Phone: (301) 496-2386. Fax: (301) 402-0055. E-mail: franchig{at}mail.nih.gov.

{dagger} Present address: Department of Allergology and Internal Diseases, Medical University of Bialystok, 15-276 Bialystok, Poland.

Journal of Virology, September 2004, p. 9740-9749, Vol. 78, No. 18
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.18.9740-9749.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2004 by the American Society for Microbiology. All rights reserved.