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Journal of Virology, September 2004, p. 10197-10201, Vol. 78, No. 18
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.18.10197-10201.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Naturally Occurring Variation in the Proline-Rich Region Does Not Attenuate Human Immunodeficiency Virus Type 1 Nef Function

Department of Virology—Universitätsklinikum, Ulm,¹ Department of Dermatology, University of Erlangen-Nürnberg, Erlangen, Germany,² Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland³

Received 9 January 2004/ Accepted 6 May 2004

We analyzed human immunodeficiency virus type 1 (HIV-1) Nef variants to further evaluate the functional relevance of the R71T substitution previously proposed to attenuate viral replication (Fackler et al., Curr. Biol. 11:1294-1299, 2001). Our results demonstrate that this variation in the proline-rich region does not significantly affect the functional activity of Nef or HIV-1 infectivity or replication.

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