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 Previous Article

Journal of Virology, September 2004, p. 9579-9583, Vol. 78, No. 17
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.17.9579-9583.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Characterization of the Human Cytomegalovirus UL34 Gene

B. J. Biegalke,* E. Lester, A. Branda, and R. Rana

Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio

Received 9 March 2004/ Accepted 16 April 2004

UL34 encodes the transcriptional repressor of the human cytomegalovirus immune evasion gene, US3, and is essential for viral replication in tissue culture. Two different monocistronic transcripts originate from UL34 at early and late times postinfection and encode two predominant proteins and a third, minor protein. The UL34 proteins are differentially expressed throughout the viral replication cycle, with both proteins localizing to the nucleus and repressing expression of the US3 gene.

* Corresponding author. Mailing address: Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, 228 Irvine Hall, Athens, OH 45701. Phone: (740) 593-2377. Fax: (740) 597-2778. E-mail: biegalke{at}ohiou.edu.

Journal of Virology, September 2004, p. 9579-9583, Vol. 78, No. 17
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.17.9579-9583.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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