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Journal of Virology, September 2004, p. 9564-9567, Vol. 78, No. 17
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.17.9564-9567.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Central Half of Pit2 Is Not Required for Its Function as a Retroviral Receptor

Pernille Bøttger1 and Lene Pedersen1,2*

Department of Molecular Biology,1 Clinical Institute, Aarhus University, Aarhus C, Denmark2

Received 24 February 2004/ Accepted 19 April 2004

The type III sodium-dependent phosphate (NaPi) cotransporter, Pit2, is a receptor for amphotropic murine leukemia virus (A-MuLV) and 10A1 MuLV. In order to determine what is sufficient for Pit2 receptor function, a deletion mutant lacking about the middle half of the protein was made. The mutant supported entry for both viruses, unequivocally narrowing down the identification of the sequence that is sufficient to specify the receptor functions of Pit2 to its N-terminal 182 amino acids and C-terminal 170 amino acids.

* Corresponding author. Mailing address: Department of Molecular Biology, Aarhus University, C. F. Møllers Allé, Bldg. 130, DK-8000 Aarhus C, Denmark. Phone: 45 8942 2633. Fax: 45 8619 6500. E-mail: LP{at}mb.au.dk.

Journal of Virology, September 2004, p. 9564-9567, Vol. 78, No. 17
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.17.9564-9567.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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