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Journal of Virology, August 2004, p. 8400-8403, Vol. 78, No. 15
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.15.8400-8403.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Virion Host Shutoff Protein of Herpes Simplex Virus Type 1 Has RNA Degradation Activity in Primary Neurons

Stephanie S. Strand,1 Tambryn K. Vanheyningen,1 and David A. Leib1,2*

Departments of Ophthalmology and Visual Sciences,1 Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 631102

Received 4 February 2004/ Accepted 1 April 2004

The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.

* Corresponding author. Mailing address: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8096, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-2689. Fax: (314) 362-3638. E-mail: Leib{at}vision.wustl.edu.

Journal of Virology, August 2004, p. 8400-8403, Vol. 78, No. 15
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.15.8400-8403.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Korom, M., Wylie, K. M., Morrison, L. A. (2008). Selective Ablation of Virion Host Shutoff Protein RNase Activity Attenuates Herpes Simplex Virus 2 in Mice. J. Virol. 82: 3642-3653 [Abstract] [Full Text]  
  • Barzilai, A., Zivony-Elbom, I., Sarid, R., Noah, E., Frenkel, N. (2006). The Herpes Simplex Virus Type 1 vhs-UL41 Gene Secures Viral Replication by Temporarily Evading Apoptotic Cellular Response to Infection: Vhs-UL41 Activity Might Require Interactions with Elements of Cellular mRNA Degradation Machinery. J. Virol. 80: 505-513 [Abstract] [Full Text]  


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