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Journal of Virology, July 2004, p. 7852-7860, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7852-7860.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Epstein-Barr Virus Latent Membrane Protein LMP-2A Is Sufficient for Transactivation of the Human Endogenous Retrovirus HERV-K18 Superantigen

Natalie Sutkowski, Gang Chen, German Calderon, and Brigitte T. Huber*

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111

Received 27 October 2003/ Accepted 17 March 2004

Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

* Corresponding author. Mailing address: Department of Pathology, 150 Harrison Ave., Boston, MA 02111. Phone: (617) 636-3989. Fax: (617) 636-0449. E-mail: brigitte.huber{at}tufts.edu.

Journal of Virology, July 2004, p. 7852-7860, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7852-7860.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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