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Journal of Virology, July 2004, p. 7846-7851, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7846-7851.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The 3' cis-Acting Genomic Replication Element of the Severe Acute Respiratory Syndrome Coronavirus Can Function in the Murine Coronavirus Genome

Scott J. Goebel, Jill Taylor, and Paul S. Masters*

Wadsworth Center, New York State Department of Health, Albany, New York 12201

Received 25 February 2004/ Accepted 23 March 2004

The 3' untranslated region (3' UTR) of the genome of the severe acute respiratory syndrome coronavirus can functionally replace its counterpart in the prototype group 2 coronavirus mouse hepatitis virus (MHV). By contrast, the 3' UTRs of representative group 1 or group 3 coronaviruses cannot operate as substitutes for the MHV 3' UTR.

* Corresponding author. Mailing address: David Axelrod Institute, Wadsworth Center, NYSDOH, New Scotland Ave., P.O. Box 22002, Albany, NY 12201-2002. Phone: (518) 474-1283. Fax: (518) 473-1326. E-mail: masters{at}wadsworth.org.

Journal of Virology, July 2004, p. 7846-7851, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7846-7851.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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