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Journal of Virology, July 2004, p. 7843-7845, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7843-7845.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lentiviral Transduction of Dendritic Cells Confers Protective Antiviral Immunity In Vivo

Shohreh Zarei,1 Shahnaz Abraham,2 Jean-Francois Arrighi,2 Olivier Haller,1 Thomas Calzascia,3 Paul R. Walker,3 Thomas M. Kündig,4 Conrad Hauser,1,2 and Vincent Piguet2*

Department of Immunology and Allergy,1 Department of Dermatology and Venereology,2 Department of Oncology, University Hospital of Geneva, Geneva,3 Dermatology Clinic, Zürich University Hospital, Zürich, Switzerland4

Received 15 January 2004/ Accepted 9 March 2004

Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.

* Corresponding author. Mailing address: Department of Dermatology and Venereology, HUG, 4-752, 24 Rue Micheli-du-Crest, 1211 Geneva, Switzerland. Phone: (4122) 372.94.65. Fax: (4122) 372.94.70. E-mail: vincent.piguet{at}medecine.unige.ch.

Journal of Virology, July 2004, p. 7843-7845, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7843-7845.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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